USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: HNRPK_HUMAN USC-OGP 2-DE database:  HNRPK_HUMAN HNRPK_HUMAN General information about the entry View entry in simple text format Entry name HNRPK_HUMAN Primary accession number P61978 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Heterogeneous nuclear ribonucleoprotein K; Short=hnRNP K; AltName: Full=Transformation up-regulated nuclear protein; Short=TUNP;. Gene name Name=HNRNPK Synonyms=HNRPK Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1129: pI=5.33; Mw=66847 SPOT OGP-1133: pI=5.37; Mw=64830 Cross-references UniProtKB/Swiss-Prot P61978; HNRPK_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name HNRPK_HUMAN Primary accession number P61978 Secondary accession number(s) Q07244 Q15671 Q59F98 Q5T6W4 Q60577 Q922Y7 Q96J62 Sequence was last modified on  June 7, 2004 (version 1) Annotations were last modified on  March 15, 2017 (version 168) Name and origin of the protein Description RecName: Full=Heterogeneous nuclear ribonucleoprotein K; Short=hnRNP K; AltName: Full=Transformation up-regulated nuclear protein; Short=TUNP; Gene name Name=HNRNPK Synonyms=HNRPK Encoded on Name=HNRNPK; Synonyms=HNRPK Keywords 3D-structure; Acetylation; Activator; Alternative splicing; Cell junction; Cell projection; Complete proteome; Cytoplasm; Direct protein sequencing; DNA-binding; Glycoprotein; Host-virus interaction; Isopeptide bond; Mental retardation; Methylation; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Ribonucleoprotein; RNA-binding; Spliceosome; Transcription; Transcription regulation; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL S74678; AAB20770.1; -; mRNA EMBL X72727; CAA51267.1; -; mRNA EMBL AB209562; BAD92799.1; ALT_INIT; mRNA EMBL AL354733; CAI16020.1; -; Genomic_DNA EMBL CH471089; EAW62675.1; -; Genomic_DNA EMBL BC000355; AAH00355.1; -; mRNA EMBL BC014980; AAH14980.1; -; mRNA CCDS CCDS6667.1; -; . CCDS CCDS6668.1; -. [P61978-2]; . PIR S43363; S43363; . RefSeq NP_001305115.1; NM_001318186.1; . RefSeq NP_001305116.1; NM_001318187.1. [P61978-3]; . RefSeq NP_001305117.1; NM_001318188.1. [P61978-1]; . RefSeq NP_002131.2; NM_002140.4. [P61978-2]; . RefSeq NP_112552.1; NM_031262.3. [P61978-1]; . RefSeq NP_112553.1; NM_031263.3. [P61978-2]; . RefSeq XP_005252017.1; XM_005251960.2. [P61978-2]; . RefSeq XP_005252020.1; XM_005251963.3. [P61978-3]; . RefSeq XP_005252022.1; XM_005251965.2. [P61978-3]; . RefSeq XP_016870157.1; XM_017014668.1. [P61978-1]; . UniGene Hs.522257; -; . PDB 1J5K; NMR; -; A=379-463 PDB 1KHM; NMR; -; A=379-463 PDB 1ZZI; X-ray; 1.80 A; A/B=385-463 PDB 1ZZJ; X-ray; 2.30 A; A/B/C=385-463 PDB 1ZZK; X-ray; 0.95 A; A=385-463 PDBsum 1J5K; -; . PDBsum 1KHM; -; . PDBsum 1ZZI; -; . PDBsum 1ZZJ; -; . PDBsum 1ZZK; -; . ProteinModelPortal P61978; -; . SMR P61978; -; . BioGrid 109431; 268; . DIP DIP-31805N; -; . IntAct P61978; 167; . MINT MINT-225422; -; . STRING 9606.ENSP00000365439; -; . iPTMnet P61978; -; . PhosphoSitePlus P61978; -; . SwissPalm P61978; -; . BioMuta HNRNPK; -; . DMDM 48429103; -; . SWISS-2DPAGE P61978; -; . MaxQB P61978; -; . PaxDb P61978; -; . PeptideAtlas P61978; -; . PRIDE P61978; -; . TopDownProteomics P61978-1; -. [P61978-1]; . DNASU 3190; -; . Ensembl ENST00000351839; ENSP00000317788; ENSG00000165119. [P61978-1]; . Ensembl ENST00000360384; ENSP00000353552; ENSG00000165119. [P61978-1]; . Ensembl ENST00000376263; ENSP00000365439; ENSG00000165119. [P61978-2]; . Ensembl ENST00000376281; ENSP00000365458; ENSG00000165119. [P61978-2]; . GeneID 3190; -; . KEGG hsa:3190; -; . UCSC uc004ang.5; human; . CTD 3190; -; . DisGeNET 3190; -; . GeneCards HNRNPK; -; . GeneCards MIR7-1; -; . HGNC HGNC:5044; HNRNPK; . HPA CAB004435; -; . HPA CAB016225; -; . HPA HPA007644; -; . HPA HPA044105; -; . MalaCards HNRNPK; -; . MIM 600712; gene; . MIM 616580; phenotype; . neXtProt NX_P61978; -; . OpenTargets ENSG00000165119; -; . PharmGKB PA162391350; -; . eggNOG KOG2192; Eukaryota; . eggNOG ENOG4111GSB; LUCA; . GeneTree ENSGT00760000119144; -; . HOVERGEN HBG051916; -; . InParanoid P61978; -; . KO K12886; -; . OMA KALRTDX; -; . PhylomeDB P61978; -; . TreeFam TF316335; -; . Reactome R-HSA-4570464; SUMOylation of RNA binding proteins; . Reactome R-HSA-72163; mRNA Splicing - Major Pathway; . Reactome R-HSA-72203; Processing of Capped Intron-Containing Pre-mRNA; . SIGNOR P61978; -; . ChiTaRS HNRNPK; human; . EvolutionaryTrace P61978; -; . GeneWiki HNRPK; -; . GenomeRNAi 3190; -; . PMAP-CutDB P61978; -; . PRO PR:P61978; -; . Proteomes UP000005640; Chromosome 9; . Bgee ENSG00000165119; -; . CleanEx HS_HNRNPK; -; . ExpressionAtlas P61978; baseline and differential; . Genevisible P61978; HS; . GO GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB; . GO GO:0042995; C:cell projection; IEA:UniProtKB-KW; . GO GO:0005737; C:cytoplasm; TAS:ProtInc; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0031012; C:extracellular matrix; IDA:BHF-UCL; . GO GO:0005925; C:focal adhesion; IDA:UniProtKB; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0000790; C:nuclear chromatin; IDA:BHF-UCL; . GO GO:0005654; C:nucleoplasm; IDA:HPA; . GO GO:0005634; C:nucleus; TAS:ProtInc; . GO GO:0002102; C:podosome; IEA:UniProtKB-SubCell; . GO GO:0045296; F:cadherin binding; IDA:BHF-UCL; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IMP:BHF-UCL; . GO GO:0003697; F:single-stranded DNA binding; TAS:BHF-UCL; . GO GO:0001077; F:transcriptional activator activity; RNA polymerase II core promoter proximal region sequence-specific binding; IMP:BHF-UCL GO GO:0010467; P:gene expression; TAS:Reactome; . GO GO:0000398; P:mRNA splicing; via spliceosome; IC:UniProtKB GO GO:0043066; P:negative regulation of apoptotic process; IMP:MGI; . GO GO:0048025; P:negative regulation of mRNA splicing; via spliceosome; IEA:Ensembl GO GO:0045716; P:positive regulation of low-density lipoprotein particle receptor biosynthetic process; IMP:BHF-UCL; . GO GO:0048260; P:positive regulation of receptor-mediated endocytosis; IMP:BHF-UCL; . GO GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL; . GO GO:1902165; P:regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IEA:Ensembl; . GO GO:0072369; P:regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL; . GO GO:0010988; P:regulation of low-density lipoprotein particle clearance; IMP:BHF-UCL; . GO GO:0006396; P:RNA processing; TAS:ProtInc; . GO GO:0007165; P:signal transduction; TAS:ProtInc; . GO GO:0016032; P:viral process; IEA:UniProtKB-KW; . Gene3D 3.30.1370.10; -; 3; . InterPro IPR033090; hnRNP_K; . InterPro IPR004087; KH_dom; . InterPro IPR004088; KH_dom_type_1; . InterPro IPR012987; ROK_N; . PANTHER PTHR10288:SF186; PTHR10288:SF186; 1; . Pfam PF00013; KH_1; 3; . Pfam PF08067; ROKNT; 1; . SMART SM00322; KH; 3; . SUPFAM SSF54791; SSF54791; 3; . PROSITE PS50084; KH_TYPE_1; 3; .

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